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Computational Toxicology: Chapter 7. Computational Translation Of Nonmammalian Species Data To Mammalian Species To Meet Reach And Next Generation Risk Assessment Needs por Edward J. Perkins

Computational Toxicology: Chapter 7. Computational Translation Of Nonmammalian Species Data To Mammalian Species To Meet Reach And Next Generation Risk Assessment Needs por Edward J. Perkins epub

Descargar Computational Toxicology: Chapter 7. Computational Translation Of Nonmammalian Species Data To Mammalian Species To Meet Reach And Next Generation Risk Assessment Needs por Edward J. Perkins Epub y PDF




Título: Computational Toxicology: Chapter 7. Computational Translation Of Nonmammalian Species Data To Mammalian Species To Meet Reach And Next Generation Risk Assessment Needs

Autores: Edward J. Perkins

Publicado: 4 de junio de 2013

ISBN: 0

Tamaño: 19 MB

Nº de páginas: 120

Idiomas: Español

Valoración: ★★★★★

Formato : PDF, EPUB


Edward J. Perkins con Computational Toxicology: Chapter 7. Computational Translation Of Nonmammalian Species Data To Mammalian Species To Meet Reach And Next Generation Risk Assessment Needs

New concepts in toxicology facilitate the use of nonmammalian vertebrate species (e.g., fish) and nonanimal models (nonvertebrates, early embryo vertebrates, or cell-based) as surrogates for mammals. We present a strategy to translate nonmammalian species data to estimate potential impact of chemicals on mammalian species based on highly conserved proteins and biological pathways linked to a defined adverse effect. Protein “targets” and pathway-level information can be mapped across species through identification of orthologs in mammals. Nonmammalian pathway data can be used to identify potential modes of action across species, establish toxicological dose-response relationships, and be used to estimate possible hazard levels of chemicals. Systems-level approaches are identified that offer unique opportunities to incorporate dynamic events such as homeostasis, effects over time, and species-specific parameters relevant to mammals. Ultimately, a pathway-centric focus enables use of alternative models to support protection of mammalian species.
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